Bone & calcium
Parathyroid hormone analogues and calcitonin.
| Compound | Research area | Residues | Highest evidence | Sequence |
|---|---|---|---|---|
| Abaloparatide | Bone & calcium | 34 | Approved drug | 34 residues |
| Calcitonin (salmon) | Bone & calcium | 32 | Approved drug | 32 residues |
| Teriparatide | Bone & calcium | 34 | Approved drug | 34 residues |
- Abaloparatide
Abaloparatide is a synthetic 34-amino-acid analogue of parathyroid hormone-related protein, PTHrP(1-34). It is an FDA-approved anabolic agent for osteoporosis, marketed as Tymlos, that acts on the PTH type 1 receptor.
- Calcitonin (salmon)
Salmon calcitonin is a 32-amino-acid peptide hormone with a disulfide-bridged ring and C-terminal prolinamide that inhibits osteoclast bone resorption. It is FDA-approved as Miacalcin for conditions including Paget's disease of bone and hypercalcemia.
- Teriparatide
Teriparatide is the N-terminal 34-amino-acid fragment of human parathyroid hormone, PTH(1-34). It is an FDA-approved bone-forming (anabolic) agent, marketed as Forteo, used for osteoporosis in people at high risk of fracture.
Comparisons in this area
- Teriparatide vs abaloparatide
Teriparatide and abaloparatide are FDA-approved anabolic peptides for osteoporosis that act at the PTH1 receptor. This page compares their origins in PTH and PTHrP, structures, proposed signaling differences, pivotal trials, regulatory status and analytical concerns.